Mechanism of positive inotropic action of helenalin, a sesquiterpene lactone in guinea-pig ventricular myocardium.
نویسندگان
چکیده
منابع مشابه
Intracellular Na+ activity and positive inotropic effect of sulmazole in guinea pig ventricular myocardium. Comparison with a cardioactive steroid.
Recent studies suggest that inhibition of Na+,K(+)-ATPase may contribute to the positive inotropic action of the imidazopyridine sulmazole. Therefore, we investigated the effect of sulmazole and its stereoisomers and for comparison the effect of the cardioactive steroid dihydroouabain (DHO) on intracellular Na+ activity by means of Na(+)-sensitive microelectrodes. In the resting papillary muscl...
متن کاملNature of the Inotropic Action of Angiotensin on Ventricular Myocardium.
• Angiotensin u has a significant positive inotropic action on mammalian ventricular myocardium. In the intact circulation this action is modified or masked by the vascular effects of angiotensin which lead to coronary vasoconstriction and to marked increases of total peripheral resistance. '~ On the other hand, when myocardial contractility is determined directly and when secondary effects of ...
متن کاملNature of the Inotropic Action of Angiotensin on Ventricular Myocardium
• Angiotensin u has a significant positive inotropic action on mammalian ventricular myocardium. In the intact circulation this action is modified or masked by the vascular effects of angiotensin which lead to coronary vasoconstriction and to marked increases of total peripheral resistance. '~ On the other hand, when myocardial contractility is determined directly and when secondary effects of ...
متن کاملPositive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria.
Endothelin (ET), a novel 21-amino acid peptide isolated from the culture supernatant of porcine aortic endothelial cells, has been shown to be the most potent of all known vasoconstrictor substances. The purpose of the present study was to investigate the effects and the mode of actions of ET on the heart. ET exerted a positive inotropic effect in a dose-dependent manner on the electrically dri...
متن کاملEffects in Guinea Pig Myocardium
no presently available drug acts predominantly as a myofilament sensitizer in situ. We have investigated the effects and the mechanism of action of novel diazinone derivatives, EMD 54622, EMD 53998, and EMD 54650 (developed by E. Merck, Darmstadt), on guinea pig myocardial preparations. Forceand ATPase-pCa relations in skinned fibers show differing potencies of these agents on myofilament sensi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1983
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)64886-9